There's a post about this already. I will copy what I wrote there:
So, this is getting funny... I didn't have any problems at all when playing the first night, but last night my GTA4 froze 3 times in less than an hour!! The first time it happened was when I finished the multiplayer tutorial; the second after leaving the game on pause for five minutes, and the third time was when I just started the sixaxis tutorial!! Everytime I had to turn off the console I had to keep pressing the on/off button for about 5 seconds. Why don't you try to do the same tutorials and pause the game to check if you are saved from this issue? Good luck!
Come on guys, has someone tried it?
Yes, I'm having the same problems, and mine is also a 60GB with an upgrade to 250GB. Had several lockups last night, and just stopped playing in the end. Played again tonight with no problem, except for my DS3 functioning incorrectly when I went into the pause menu. The only button that would work was the PS button (i.e. couldn't scroll through menus or exit the pause menu using circle). I used the PS button to turn off the controller, and turned it back on again - was fine after that. However, on exiting the game via the PS button menu, the PS3 paused for ages before giving three beeps and shutting down (rather than going back to the XMB).
My PS3 is a 60GB version recieved on launch day ,recently upgraded with 250GB HDD, no problems with other games at all either ,what about anyone else?